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Skip Navigation LinksKCC Home > Academic Departments > Biological Sciences > 11New > Webpages > Unit 4, Lesson 4

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Anatomy and Physiology I
Unit 1: Introduction to Human Anatomy and PhysiologyExpand Unit 1: Introduction to Human Anatomy and Physiology
Unit 2: The Cell and It’s EnvironmentExpand Unit 2: The Cell and It’s Environment
Unit 3: Cellular ChemistryExpand Unit 3: Cellular Chemistry
Unit 4: Biomolecules, Cell Architecture and Cellular Molecular FunctionExpand Unit 4: Biomolecules, Cell  Architecture and Cellular Molecular Function
Unit 5: Tissues, Membranes and GlandsExpand Unit 5: Tissues, Membranes and Glands
Unit 6: Integumentary SystemExpand Unit 6: Integumentary System
Unit 7: Skeletal System
Unit 8: Muscular System
Unit 9: Nervous System Introductory Concepts
Unit 10: The Central Nervous System - The Spinal Cord
Unit 11: The Central Nervous System - The Brain
Unit 12: The Autonomic Nervous System and Smooth Muscle

Lesson 4 - The Lipids - Introduction, Functions, and Demonstration

Student Performance Objectives
1. Define hydrophobic and hydrophilic.
2. Draw a schematic diagram of a triglyceride showing glycerol and three fatty acids.
3. Compare the energy storage by triglycerides compared with carbohydrates and proteins.
4. Explain the similarities and differences between fats and oils.
5. Define saturated, monounsaturated and polyunsaturated with regard to fatty acids.
6. Explain how the natural products, olive oil and corn oil, are referred to as monounsaturated or
    polyunsaturated, respectively.
7. Describe 5 functions for lipids in the human body.

Lesson Outline
A. Definitions and general information
    1. For a good general introduction to the lipids with a description and showing structures,
    see:
http://www.biology.clc.uc.edu/courses/bio104/lipids.htm
    2. Hydrophobic in general - critical in construction of cellular membranes separating
        fluid compartments inside and outside cells, and inside and outside organelles.
        Distinguish hydrophobic from hydrophilic. 

        http://www.uic.edu/classes/bios/bios100/lectures/membranes01.htm

        For an animated view of the relationship of lipids and water, see
        
http://www.johnkyrk.com/cellmembrane.html
    3. Examples: natural substances like vegetable oils, butter, and lard are mostly triglycerides.
        To understand a triglyceride, start with the idea of a fatty acid:
        Structure of a fatty acid:
       
 http://www-medlib.med.utah.edu/NetBiochem/FattyAcids/3_3.html
        If desired, the naming of the alpha and omega carbon atoms in a fatty acid may be observed at:
        
http://www-medlib.med.utah.edu/NetBiochem/FattyAcids/4_1d.html
        Generalized triglyceride structure:
       
 http://www.biology.clc.uc.edu/courses/bio104/lipids.htm
    4. Triglycerides are energy dense (9 kcal/gram) - useful for energy storage. Note -
        carbohydrates and proteins, when burned for energy, yield 4 kcal/gram.
    5. Fats are triglycerides that are solid at room temperature; oils are triglycerides that are liquid at room
        temperature.
        a. Triglycerides are the combination of a glycerol molecule and 3 fatty acids.
        Review:
http://www.biology.clc.uc.edu/courses/bio104/lipids.htm
        b. The fatty acids may be saturated, monounsaturated or polyunsaturated.
    6. Being solid or liquid at a given temperature depends on the degree of saturation of the
        fatty acids composing the triglycerides of the given substance. A monounsaturated
        vegetable oil like olive is liquid at room temperature. A polyunsaturated oil like
        safflower remains as a liquid even in the refrigerator, where the olive oil solidifies. A
        saturated fat like lard or butter is solid at room temperature and becomes harder in
        texture in the refrigerator.
    7. One double bond in the carbon chain of a fatty acid makes the molecule monounsaturated. Two or
        more double bonds in the fatty acid's carbon chain makes
        the molecule polyunsaturated. No double bonds in the carbon chain of a fatty acid
        makes the molecule saturated.
B. Functions of lipids in the human body.
    1. Insulation
    2. Cushioning - our soft internal organs need protection from our endoskeleton.
    3. Cell membranes - utilize phospholipids and cholesterol in their structure. 
        a. Concept of the amphiphilic molecule - one end hydrophobic; the other end
            hydrophilic.
        b. Phospholipids are made by removing one fatty acid from a triglyceride and
            substituting a phosphate group which is hydrophilic. Structure of a phospholipid:  
            https://answers.yahoo.com/question/index?qid=20120218191339AAmSqFI
       
         c. To observe the placement of phospholipid molecules composing cellular
            membranes, see:
             http://micro.magnet.fsu.edu/cells/plasmamembrane/plasmamembrane.html
     4. Hormone production
        a. Steroid hormones like estrogens and androgens.
        b. Eicosanoids like the prostaglandins, leukotrienes and thromboxanes.
     5. Heat generation (brown fat). Seen extensively in newborn babies.
     6. Energy storage.
     7. Appetite satiety and food flavour and texture enhancement.
C. DEMONSTRATION: lipid characteristics. Compare coconut oil, butter, olive oil and safflower oil.
     Note that the coconut oil is solid at room temperature (~ 70º F) as is butter (although it is soft).
     Note that olive oil is solid at refrigerator temperatures (~ 40º F) but liquid at room temperature, and
     that safflower oil is liquid at both refrigerator and room temperatures. All of these physical
     observations are based on the degree of saturation of the lipids being observed.
     (These effects are also due, in part, to the chain length of the fatty acids, particularly in the coconut oil
     which contains relatively short chain length fatty acids).












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